ABO grouping

ABO grouping is based on the presence or absence of two surface antigens (chemicals that can induce immune response) on the RBCs namely A and B.

Similarly, the plasma of different individuals contain two natural antibodies (proteins produced in response to antigens). The distribution of antigens and antibodies in the four groups of blood, A, B, AB and O are given in Table.

You probably know that during blood transfusion, any blood cannot be used; the blood of a donor has to be carefully matched with the blood of a recipient before any blood transfusion to avoid severe problems of clumping (destruction of RBC). The donor’s compatibility is also shown in the Table.


Blood Group Antigens on RBCs Antibodies In Plasma Donor’s Group
A A anti-B A, O
B B anti-A B, O
AB A, B nil AB, A, B, O
O nil anti-A,B O

From the above mentioned table it is evident that group ‘O’ blood can be donated to persons with any other blood group and hence ‘O’ group individuals are called ‘universal donors’.

Persons with ‘AB’ group can accept blood from persons with AB as well as the other groups of blood. Therefore, such persons are called ‘universal recipients’.

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